{"id":325,"date":"2022-06-22T10:51:23","date_gmt":"2022-06-22T08:51:23","guid":{"rendered":"https:\/\/tonetx.eu\/home\/"},"modified":"2023-08-28T14:33:49","modified_gmt":"2023-08-28T12:33:49","slug":"home","status":"publish","type":"page","link":"https:\/\/tonetx.eu\/en\/","title":{"rendered":"HOME"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; background_video_mp4=&#8221;https:\/\/tonetx.eu\/wp-content\/uploads\/2023\/02\/iStock-1317698020.mov&#8221; min_height=&#8221;500px&#8221; height=&#8221;600px&#8221; max_height=&#8221;600px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_slider _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;Arial||||||||&#8221; header_line_height=&#8221;1.3em&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; background_enable_video_mp4=&#8221;off&#8221; background_video_width=&#8221;100%&#8221; background_video_height=&#8221;100%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;100px||||false|false&#8221; header_text_shadow_style=&#8221;preset2&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_slide heading=&#8221;T-ONE THERAPEUTICS&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; header_level=&#8221;h2&#8243; header_font_size=&#8221;70px&#8221; body_font=&#8221;|600|||||||&#8221; body_font_size=&#8221;24px&#8221; body_letter_spacing=&#8221;1px&#8221; body_line_height=&#8221;1.8em&#8221; header_text_shadow_style=&#8221;preset2&#8243; body_text_shadow_style=&#8221;preset2&#8243; text_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221; sticky_transition=&#8221;on&#8221;]<span style=\"font-weight: bolder;\">AWAKENING THE IMMUNE RESPONSE AGAINST THE TUMOR AND AUTOIMMUNE DISEASES<\/span><\/p>\n<p>Finding safer and effective therapeutic approaches for cancer and autoimmune diseases.[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_stops=&#8221;#ffffff 0%|#e8eefc 100%&#8221; background_color_gradient_start=&#8221;#ffffff&#8221; background_color_gradient_end=&#8221;#e8eefc&#8221; custom_padding=&#8221;76px|0px|99px|0px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|auto||0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Arial||||||||&#8221; text_text_color=&#8221;#1d1d1b&#8221; text_font_size=&#8221;15px&#8221; text_line_height=&#8221;2em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;Josefin Sans|700|||||||&#8221; header_2_text_color=&#8221;#b5bf0e&#8221; header_2_font_size=&#8221;42px&#8221; header_2_line_height=&#8221;1.5em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;1128px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|-206px||-131px||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: justify;\">ABOUT US<\/h2>\n<p style=\"text-align: justify;\">T-One Therapeutics stems from the vision of a group of researchers aiming to exploit innovative RNA-based therapies to fight a wide spectrum of human pathologies, like cancer and autoimmune diseases.<\/p>\n<p style=\"text-align: justify;\">The mission of T-One Therapeutics is to develop a novel pharmacological approach to specifically target RNA molecules transcribed from repetitive sequences of the human genome called LINE1 elements. We recently discovered that LINE1-derived RNAs accumulate in the nuclei of T lymphocytes with an impaired immune effector function, as dysfunctional T cells derived from tumor tissues<\/p>\n<p style=\"text-align: justify;\">Importantly, we found that pharmacological inhibition of LINE1-derived RNAs through antisense oligonucleotides (ASOs) in TILs (Tumor Infiltrating Lymphocytes) reinvigorates the immune response against tumors. Thus, LINE1 represent a promising therapeutic target to modulate the immune response in several pathological contexts.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_padding=&#8221;15px|15px|15px|15px|false|false&#8221; border_width_top=&#8221;12px&#8221; border_color_top=&#8221;gcid-0881eb85-6db4-495d-84c3-350d3a9274f0&#8243; box_shadow_style=&#8221;preset1&#8243; global_colors_info=&#8221;{%22gcid-0881eb85-6db4-495d-84c3-350d3a9274f0%22:%91%22border_color_top%22%93}&#8221;][et_pb_blurb title=&#8221;OBJECTIVES&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xf471;||fa||900&#8243; icon_color=&#8221;#ffffff&#8221; image_icon_background_color=&#8221;#b5bf0e&#8221; image_icon_width=&#8221;40px&#8221; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;Lato|900||on|||||&#8221; header_font_size=&#8221;25px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;Lato||||||||&#8221; body_text_color=&#8221;#898f99&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.6em&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; image_icon_custom_padding=&#8221;25px|25px|25px|25px|false|false&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px|40px|0px|40px|false|false&#8221; animation=&#8221;off&#8221; border_color_all=&#8221;RGBA(255,255,255,0)&#8221; border_style_all=&#8221;none&#8221; border_width_top=&#8221;10px&#8221; border_color_top=&#8221;#b5bf0e&#8221; border_radii_image=&#8221;on|100%|100%|100%|100%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][et_pb_text _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Arial||||||||&#8221; text_font_size=&#8221;18px&#8221; text_line_height=&#8221;1.8em&#8221; text_orientation=&#8221;center&#8221; global_colors_info=&#8221;{}&#8221;]<strong>To develop a novel RNA-based immunotherapy approach to treat cancer and autoimmune diseases through the targeting of LINE1 elements.<\/strong>[\/et_pb_text][et_pb_button button_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE3MyJ9fQ==@&#8221; button_text=&#8221;READ&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.19.4&#8243; _dynamic_attributes=&#8221;button_url&#8221; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221; custom_padding=&#8221;15px|15px|15px|15px|false|false&#8221; 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