Giacomo Grillo, PhD

Researcher

grillo@tonetx.eu

+ 39 0200660350

Giacomo is a scientist with years of experience in the study of chromatin and of the repetitive genome in physiology and pathology. After a bachelor in Molecular Biotechnology at Milano-Bicocca University, he joined a double-degree program between Milano-Bicocca University and Paris Diderot (Paris 7) University, obtaining a master in Industrial Biotechnology and one in Genetics at Paris Diderot (Paris 7) University. In 2017, he obtained a PhD in Hematology and Oncology at Paris Diderot (Paris 7) University, where he studied the DNA methylation process during the early embryonal development and in pathological context of the rare genetic syndrome known as ICF (Immunodeficiency, Centromeric instability and Facial anomalies). His research focused on the repetitive genome, especially on centromeres, peri-centromeres and transposable elements. Giacomo then moved as postdoctoral researcher to the Department of Medical Biophysics at University Health Network (UHN) in Toronto (Canada) to investigate the role of transposons in physiology and oncology. He focused on studying chromatin changes at transposable elements from stem cells to normal tissues up to cancer tissues and on the oncogenic role of these elements in prostate cancer, breast cancer and acute myeloid leukemia. During his career, Giacomo trained master and PhD students and mentored technicians and junior postdoctoral researchers.

Giacomo has a keen interest in targeting transposable elements for therapeutic intervention in oncology, in line with T-One Therapeutics strategy. His knowledge of repetitive genome, and his expertise in the analysis of transposable elements and of state-of-the-art molecular biology techniques are valuable assets in the quest for re-activating the immune system in order to limit tumor growth through the use of antisense oligonucleotides.